Reproductive and Developmental Toxicity of Cryptolepis sanguinolenta in Mice

The clinical efficacy of cryptolepis sanguinolenta in the treatment of malaria.

The roots of cryptolepis, also known as nibima, kadze, gangamau, Ghanaian quinine and yellow-dye root (Cryptolepis sanguinolenta) have been used in Ghanaian traditional medicine for treatment of malaria for many generations. A Ghanaian drug company developed an herbal tea formulation trademarked as PhytoLaria based on this plant, and the clinical evaluation of its potential as a herbal drug tre...

Evidence on the Developmental and Reproductive Toxicity

Treatment of falciparum malaria with a tea-bag formulation of cryptolepis sanguinolenta root.

2 4. Kirby GC, Paine A, Warhurst DC, Noamesi BK, Phillipson JD. In vitro and in vivo antimalarial activity of cryptolepine, a plant-derived indoloquinoline. Phytother Res 1995; 9: 359-363 5. Noamesi BK, Paine A, Kirby GC, Warhurst DC, Phillipson JD. In vitro antimalarial activity of cryptolepine, an indoquinoline. Trans Roy Soc Trop Med Hyg 1991; 85:315 6. Boye GL. Studies on antimalarial actio...

Changes in Reproductive Hormones Secretion Involved in Quantum Dots-induced Reproductive Toxicity in Adult Male Mice

Background and Aims: Quantum dots (QDs), as colloidal nanocrystalline semiconductors, present QD wavelengths in terms of biomedical assays and imaging, though the high toxicity of their core demands to be taken into consideration. Investigating this subject is taken into account as an important concept   concerning use of these nanoparticles in the medical applications. Materials a...

Reproductive and Developmental Toxicity of Amitraz in Sprague-Dawley Rats

The present study was conducted to obtain information on the effects of amitraz on reproductive and developmental parameters in rats. The test chemical was administered via the drinking water containing 0, 40, 120, and 360 ppm to male rats from 2 weeks before mating to the end of 14-day mating period and to females from 2 weeks before mating, throughout mating, gestation and up to lactational d...